T: +44(0)1625 665 999 F: +44(0)1625 665 998
Almac Pharma Services concluded that the process would be more efficient and cost effective if a large blender was used to meet the increased production capacity whilst ensuring the accuracy of the finished drug product. Trials at Kek-Gardner’s technology centre confirmed that the equipment would meet the stringent cGMP standards as detailed in the URS both in terms of throughput and product quality. As a result a blending suite comprising a Gardner 4200 litre working capacity Double Cone Blender, a Gardner 700 litre working capacity Y Cone Blender and a Kek K650CV inline Vacuum Centrifugal Sifter, tied together by lean phase pneumatic conveying was installed at Almac Pharma Services.
The process begins with a premix of salts and the active pharmaceutical bulk material, which is initially sifted in the K650CV Sifter and transferred to the 700 litre working capacity Y Cone Blender for preliminary blending. The pre mixed material is then conveyed to the 4200 litre Double cone Blender where it is blended along with the rest of the active pharmaceutical bulk material. The material is then discharged into a Matcon bin and transferred to the Mediseal LA 500 / P1600 packing line for processing into finished sachets.
GARDNER Blenders are part of a comprehensive range of mixing equipment supplied by Kek-Gardner, which also includes Plough and Ribbon Mixers. In addition, Kek-Gardner also supplies the full range of Size Reduction Mills, Air Classifier Mills and Centrifugal Sifters.
Kek-Gardner’s intimate knowledge of the pharmaceutical industry enables them to produce bespoke equipment to meet the demands of the major pharmaceutical companies and their regulatory authorities and are prepared to work with each customer to offer a process solution to any application requirement.
The full scope of Kek-Gardner’s products can be seen on their web site at www.kekgardner.com. Alternatively, to discuss a specific application, contact them on +44 (0) 1625 665999.
Almac Pharma Services is an FDA approved global outsourcing partner with over 30 years' experience in the development and manufacture of solid oral dose products. Their capabilities include: formulation and analytical development, clinical and commercial-scale drug manufacture, primary and secondary packaging and labelling, EU import testing, QP release and global supply chain management to end-users.
